Early Lab Study: Hemp Shows Therapeutic Potential for Reducing Ovarian Cancer Risk

Could non-psychoactive hemp be a viable use to reduce ovarian cancer risk? As we learn more about the bioactives in hemp, the possibility becomes ever real. At the 2018 annual Experimental Biology meeting in San Diego, graduate students, Sara Biela and Chase Turner, presented the first study to examine hemp and its ability to fight cancer. The results show that it may one day be useful as plant-based formula for reducing ovarian cancer risk.

Beila and Chase led two new studies that examined the therapeutic potential of an extract known as KY-hemp and ovarian cancer hemp, which is produced from non-psychoactive hemp grown in Kentucky. The plant strain, growing conditions and processing techniques were all optimized to produce an extract containing substances with potential therapeutic benefit and to eliminate any residue that could contaminate the product.

In one study, the researchers found that adding various doses of KY-hemp extract to cultured ovarian cells led to significant dose-dependent slowing of cell migration. This finding indicated that the extract might be useful for stopping or slowing down metastasis.

In a second study, the researchers explored the biology of KY-hemp’s protective effects against ovarian cancer, which they had observed in previous studies. Experiments with cultured ovarian cancer cells showed that KY-hemp slowed the secretion of the interleukin IL-1 beta. Interleukins produce inflammation that can be damaging and has been linked to cancer progression. The hemp-induced slowing of IL-1 β secretion represents a possible biological mechanism responsible for KY-hemp’s anti-cancer effects.

Our findings from this research as well as prior research show that KY hemp slows ovarian cancer comparable to or even better than the current ovarian cancer drug Cisplatin,” said Turner. “Since Cisplatin exhibits high toxicity, we anticipate that hemp would carry less side effects. However, that needed to be tested in the future.”

The researchers plan to test the extract in mice after they complete additional studies in cultured cancer cells to learn more about how it leads to cancer cell death.

Source: Experimental Biology 2018, KY Hemp-induced Modulation of Ovarian Cancer Cell Metastasis; Investigate Kentucky Hemp-Induced Modulation of Interleukin-1 β Secretion in Ovarian Cancer Cells