It is well known among researchers that mitochondrial genetic or primary mitochondrial disorders contribute to mitochondrial dysfunction as well as secondary or acquired degenerative disorders. This review will concentrate on nongenetic or acquired mechanisms that could explain mitochondrial dysfunction and their replacement treatment with natural supplements and combinations of natural supplements, including vitamins, minerals, enzyme cofactors, antioxidants, metabolites, transporters, membrane-type phospholipids, and other natural supplements. Combinations of supplements can reduce significantly the fatigue and other symptoms associated with chronic disease and can naturally restore mitochondrial function, even in long-term patients with intractable fatigue. By Garth Nicholsen, PhD, published in Alternative Therapies Health Med. 2014, Vol. 20, Suppl. 1.
In 2013, a study, Immunomodulatory Effects of ResistAid™: A Randomized, Double-Blind, Placebo-Controlled, Multidose Study, evaluated the ability of a proprietary arabinogalactan extract from the larch tree (ResistAid™, Lonza Ltd., Basel, Switzerland) to change the immune response in healthy adults to a standardized antigenic challenge of tetanus and influenza vaccines in a dose-dependent manner compared to placebo. As it is flu season, Today’s Practitioner is revisiting the study and the subject with an interview with Bryan Rodriguez, Global Products Manager, of Lonza, makers of Resist Aid. Download the full study at the end of this article.
Little agreement exists as to whether low-level mercury (Hg) exposure causes damage to the central nervous system in adults. Although eating fish is associated with intake of methylmercury, researchers in this field have generally thought that the beneficial effects of a diet rich in long-chain, n-3 fatty acids (N3FA) can outweigh the cognitive neurotoxicity of mercury. This study clarifies the impact of Hg and intake of seafood on cognition. By Steven C. Masley, MD, FAAFP, CNS, FACN; Lucas V. Masley; C. Thomas Gualtieri, MD, published in Integrative Medicine a Clinicians Journal
Breast cancer (BC) is the most common cancer in women, with over 1 million new cases diagnosed
every year worldwide. Over recent decades, considerable interest has emerged regarding whether vitamins and/or other supplements can lower the risk of BC. However, previous epidemiologic studies that investigated the association between intake of multivitamin and supplements of single vitamins and minerals and BC risk have reported conflicting results. Whether vitamins can actually reduce BC risk is still controversial. This study examined whether multivitamin and calcium use was associated with BC incidence and DNA repair capacity (DRC).
Why do patients resist prescriptive actions? Clearly their reasons are complex, reflecting intentional as well as nonintentional factors. Behavioral research suggests that people fail to follow prescriptive actions when they do not understand potential benefits, when they do not believe they can change, or when they lack an effective plan and reliable social support. Patients may feel uncomfortable about clinicians’ recommendations because they
do not feel understood or they feel they do not have the time or energy to make the necessary lifestyle changes due to recurrent work-family daily pressures. This report addresses a novel means to improve patient compliance, called Insight-Motivated Learning.
The cellular environment is sensitive to the presence of free radicals, which are molecules with unpaired electrons. The most common types of free radicals are formed from the elements oxygen, nitrogen, carbon, sulfur, and chlorine. Cells continually need to balance redox potential (the tendency to gain or lose electrons). This potential can be skewed toward oxidation (a tendency to lose electrons), called oxidative stress, or reduction (a tendency to gain electrons), called reductive stress.
This archived case study Dan Lukaczer, ND is a useful model for practitioners seeking to develop a nutritional approach to treating arthritic symptoms. As Lukaczer points out in this case study, the relationship between rheumatoid arthritis [or any form of arthritis] and the myriad potential environmental triggers is beyond the scope of this report. Instead, this paper addresses the use of a focused nutritional support program and discusses select environmental influences to illustrate the rationale behind this clinical approach. Given the complexity of RA, no one approach can benefit all patients, but it is hoped that the case illustrated here will show how a nutritional program can be personalized, leading to a clinically-beneficial result. Registered users and Today’s Practitioner members can access the entire case study.
Integrative Nutritional Approach to the Treatment of Rheumatoid Arthritis, Published in Integrative Medicine, A Clinician’s Journal Vol. 4, No. 2 by Dan Lukaczer, ND
It’s not often that you hear a doctor use words like “remarkable” and “most clinically important lectures ever,” when referring to a conference lecture. Those were Joe Pizzorno’s ND words from a lecture by Alessio Fasano, MD at the Institute for Functional Medicine (IFM) conference in Dallas, Texas in MayRead …