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Osteoinductive Protein Complex for Moderate to Severe Osteoarthritis

Richard Garian, DC, MS; Arlene Donar, ND; Donald DeFabio, DC; Nancy Gahles, DC; James J. Scaffidi, BS


Context: Osteoarthritis, also known as degenerative joint disease, is one the most common forms of joint disorder in the United States and affects over 20 million people. Current treatments for its management involve the use of analgesics such as acetaminophen and nonsteroidal, anti-inflammatory drugs (NSAIDs). These treatments, however, have shown limited effectiveness, and in some cases, have produced severe side effects, including GI conditions, internal bleeding, and kidney damage.

Objective: The study intended to demonstrate the clinical effects of a novel protein complex, Cyplexinol, in combination with glucosamine and chondroitin, in the regenerative stimulation of bone and cartilage to reduce pain and increase joint flexibility in healthy individuals with degenerative joint disease due to osteoarthritis.

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