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Doctors Rethink Calcium and Fracture Risk Advice

Doctor’s hardened advice to take calcium to prevent age-related fractures is softening. Two studies in the British Medical Journal released in October 2015, shows that increasing calcium intake through dietary sources or supplements does nothing to improve bone health or prevent fractures in older people. The studies suggest that increasing calcium intake should not be recommended for fracture prevention.

To date, supporting studies that dissuade calcium recommendations for bone fracture risk reduction have done little to change health recommendations from bastions of health information like the National Institutes of Health. Current guidelines from the NIH recommend the following:

“Women over age 50 should consume 1,200 mg of calcium daily. Men between the ages of 51 and 70 should consume 1,000 mg of calcium a day, and men over 70 should consume 1,200 mg per day. This can be done by eating calcium-rich foods and taking calcium supplements. men and women over 50 consume 1200.”

Documented studies regarding health concerns and kidney stone formation, vascular events and acute gastrointestinal events have prompted some experts to recommended that people over age 50 increase their calcium intake through their diet and resort to supplements only when dietary sources are not possible. For instance, Osteoporosis Canada, says that even though concerns exist regarding calcium and kidney stone formation, they still make the following recommendation.

“Based on all research to date, Osteoporosis Canada still recommends that those who are 50 years of age or more take 1200 mg of elemental calcium daily, preferably from dietary sources, and 800-2000 IU of a vitamin D supplement daily.”

Vintage Milk BottlesThese new studies presented in BMJ, led by researchers in New Zealand, examined the evidence that underpins the recommendation that by increasing calcium intake from dietary sources or supplements one can improve bone health and prevent fractures.

The researchers used bone mineral density (BMD) as the surrogate endpoint for fracture risk in randomized controlled trials of modest size. They analyzed the available evidence from randomized controlled trials and observational studies of extra dietary or supplemental calcium in women and men aged over 50. Study design was considered when determining which studies to include.

STUDY METHOD

Researchers identified 59 eligible randomized controlled trials: 15 studied dietary sources of calcium (n=1533) and 51 studied calcium supplements (n=12 257).

RESULTS

Increasing calcium intake from dietary sources increased BMD by 0.6-1.0% at the total hip and total body at one year and by 0.7-1.8% on respective sites in the lumbar spine and femoral neck at two years. There was no effect on BMD in the forearm.

Calcium supplements increased BMD by 0.7-1.8% in all five skeletal sites at one, two, and over two and a half years. However, the size of the increase in BMD at later time points was similar to the increase at one year.

Increases in BMD were similar in trials of dietary sources of calcium and calcium supplements (except at the forearm), in trials of calcium monotherapy versus co-administered calcium and vitamin D, in trials with calcium doses of ≥1000 versus <1000 mg/day and ≤500 versus >500 mg/day, and in trials where the baseline dietary calcium intake was <800 versus ≥800 mg/day.

CONCLUSION

In the first study, researchers reported that increasing calcium intake from dietary sources or by taking supplements produced small (1-2%) increases in bone mineral density, which “are unlikely to lead to a clinically meaningful reduction in risk of fracture.”

In the second study, researchers concluded that dietary calcium intake is not associated with risk of fracture. They found no clinical trial evidence that increasing calcium intake from dietary sources prevents fractures.

It is time to revisit recommendations to increase calcium intake beyond a normal balanced diet, said Professor Karl Michaëlsson from Uppsala University in Sweden, in an accompanying editorial.

He pointed out that ever increasing intakes of calcium and vitamin D recommended by some guidelines defines virtually the whole population aged over 50 at risk. Yet most will not benefit from increasing their intakes, he warns, and will be exposed instead to a higher risk of adverse events. “The weight of evidence against such mass medication of older people is now compelling, and it is surely time to reconsider these controversial recommendations,” he concludes.

Mark J Bolland, William Leung, Vicky Tai, Sonja Bastin, Greg D Gamble, Andrew Grey, Ian R Reid. Calcium intake and risk of fracture: systematic review. BMJ, 2015; h4580 DOI: 10.1136/bmj.h4580

 

 

 

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