Research presented at European Academy of Dermatology and Venereology (EADV) 29th Congress/EADV Virtual (Oct 30-31, 2020), shows promise that a form of vitamin B3 (nicotinamide, NAM) could protect skin cells from the effects of ultraviolet (UV) exposure: the main risk factor for non-melanoma skin cancers (1).
Researchers in Italy isolated cells (human primary keratinocytes) from the skin of patients with non-melanoma skin cancers. These cells were treated with three different concentrations of nicotinamide (NAM), a form of vitamin B3, for 18, 24, and 48 hours and then exposed to UVB.
Results show that pre-treatment with 25μM of NAM 24 hours before UV irradiation protected the skin cells from the effects of UV-induced oxidative stress, including DNA damage.
- NAM enhanced DNA repair, demonstrated by decreased expression of the DNA repair enzyme OGG1.
- Furthermore, it decreased antioxidant expression and blocked local inflammation by showing decreased nitric oxide (NO) release and reactive oxygen species (ROS) production, and reduced iNOS protein expression.
“Our study indicates that increasing the consumption of vitamin B3, which is readily available in the daily diet, will protect the skin from some of the effects of UV exposure, potentially reducing the incidence of non-melanoma skin cancers. However, the protective effect of vitamin B3 is short-acting, so it should be consumed no later than 24 to 48 hours before sun exposure,” said Lara Camillo, a research student from the Dermatological Unit of AOU Maggiore della Carità, Novara, Italy.
Non-melanoma skin cancers are the most common malignancies in the Caucasian population and incidence is increasing worldwide. The main risk factor is UV radiation exposure, which damages the DNA, increases ROS production, activates local inflammation, and depletes cellular energy, leading to genomic instability and cell death.
This year’s Congress is a first in EADV’s history. EADV Virtual – New Frontiers in Dermatology and Venereology provides an exceptional opportunity for colleagues from around the world to explore the latest developments in science and patient care that are at the heart of the academy’s mission. The user experience is immersive and simple to follow. To find out more visit https://eadvvirtualcongress.org/
(1) Camillo L et al. THE ROLE OF NICOTINAMIDE IN PHOTOPROTECTION OF HUMAN PRIMARY KERATINOCYTES FROM OXIDATIVE STRESS DAMAGES UV-INDUCED. Late breaking abstract no 3109 EADV Virtual, 29-31 October 2020.
(2) Cancer.org. Basal and Squamous Cell Skin Cancer. Available at: https://www.cancer.org/cancer/basal-and-squamous-cell-skin-cancer.html Accessed October 2020
(3) Cancer.org. What is Melanoma. Available at: https://www.cancer.org/cancer/melanoma-skin-cancer/about/what-is-melanoma.html Accessed October 2020
(4) WCRF. Skin Cancer Statistics. Available at: https://www.wcrf.org/dietandcancer/cancer-trends/skin-cancer-statistics Accessed October 2020