In the realm of healthy aging, a realm where time and science converge, lies a treasure trove of potent key nutrients and topical wonders that can transform the way we approach the aging process. Here we’ll explore the therapeutic properties of L-Baiba, ac-11 cat’s claw, 2-HOBA, bergamot, and spermidine – ingested elixirs that nourish our very core while discovering the inherent powers of PTD-DBM, copper tripeptide-1, zinc thymulin, GHK-Cu, Argireline, and Leuphasyl – topical marvels that adorn our skin with youthfulness.
Key Nutrients- Ingestible Ingredients
L-Baiba is an emerging nutrient known for its remarkable anti-aging properties. As a product of thymine nucleotide catabolism in mitochondria, L-Baiba has been linked to improved insulin sensitivity and reduced metabolic risk factors.(1) Its mechanism of action involves activating the AMPK (AMP-activated protein kinase) signaling pathway, which regulates cellular energy metabolism and mitigates oxidative stress-induced cellular damage. Preliminary research suggests that L-Baiba supplementation may be beneficial in mitigating age-related metabolic impairments, such as insulin resistance and dyslipidemia, making it a potential addition to personalized treatment plans for aging individuals with metabolic syndrome or related conditions.
Ac-11 cat’s claw, derived from the Uncaria tomentosa plant, has garnered attention for its DNA repair and antioxidant capabilities. Carboxyl alkyl esters in ac-11 cat’s claw stimulate the repair of damaged DNA, primarily through upregulating DNA repair enzymes like poly(ADP-ribose) polymerase (PARP). (2) Moreover, ac-11 cat’s claw acts as a potent antioxidant, neutralizing free radicals and safeguarding cellular structures from oxidative damage. Importantly, ac-11 cat’s claw has been found to provide protection against UVA (ultraviolet A) and UVB (ultraviolet B) light exposure, two types of UV radiation emitted by the sun that contribute to skin damage and aging. Its DNA repair capabilities help maintain genomic stability in skin cells, reducing the risk of DNA mutations and potential skin cancer development caused by UV radiation (3). Clinically, ac-11 cat’s claw’s DNA repair and antioxidant properties hold promise as a supplement for individuals experiencing DNA damage due to aging or environmental factors and may contribute to preventing age-related diseases associated with genetic instability, such as cancer.
2-HOBA (2-hydroxybenzylamine) emerges as a formidable force in the battle against chronic inflammation, wielding its natural antioxidant might to protect cellular health. Through its remarkable ability to scavenge free radicals, 2-HOBA sweeps away the harmful molecules that contribute to oxidative stress and cellular damage. But that’s not all – this mighty compound goes a step further by inhibiting pro-inflammatory signaling pathways, including the notorious nuclear factor-kappa B (NF-κB), the master regulator of inflammation.(4) As 2-HOBA takes center stage, it orchestrates a symphony of anti-inflammatory effects, taming the raging flames of chronic inflammation that can wreak havoc on the body. By dampening the pro-inflammatory signaling cascade, it brings tranquility to the cellular environment, ensuring that inflammatory responses are kept in check. The profound implications of 2-HOBA’s actions are far-reaching, making it an ideal ally for aging individuals grappling with chronic inflammatory conditions such as osteoarthritis or atherosclerosis. With chronic inflammation often driving the progression of these age-related ailments, 2-HOBA’s anti-inflammatory properties offer a ray of hope. Its soothing influence may not only alleviate painful symptoms but also enhance overall well-being, empowering individuals to savor the joys of life unhindered by the burden of inflammation.
Bergamot, a citrus fruit rich in flavonoids and polyphenols, contains bergamot polyphenolic fraction (BPF) that exhibits antioxidant and lipid-lowering effects. BPF enhances the expression of antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), thereby protecting cells from oxidative stress (5). Additionally, BPF inhibits cholesterol synthesis by targeting HMG-CoA reductase, a key enzyme involved in cholesterol production. Bergamot supplementation may be beneficial for aging individuals with dyslipidemia or high cholesterol levels, as it can reduce oxidative stress and improve lipid profiles, thereby promoting cardiovascular health and preventing age-related cardiovascular diseases.
Spermidine, a polyamine found in various foods, has the unique ability to induce autophagy, a cellular process that recycles damaged organelles and proteins. The induction of autophagy occurs through the inhibition of acetyltransferase EP300, leading to the activation of autophagy-related genes (6). This process promotes cellular rejuvenation and has even shown promise in extending lifespan in preclinical studies. While more research is needed to establish its long-term effects in humans, doctors may consider recommending spermidine-rich diets or supplements to support healthy aging and cellular renewal.
Topical Ingredients
PTD-DBM (Protein Transduction Domain-Derived Decoy Molecule) is a peptide with remarkable tissue repair and regeneration properties. Acting as a decoy molecule, PTD-DBM competes with transcription factors involved in inflammation, leading to a reduction in the production of pro-inflammatory cytokines (7). Furthermore, PTD-DBM enhances fibroblast migration and collagen synthesis, facilitating wound healing and promoting skin rejuvenation. Its ability to reduce inflammation and promote tissue regeneration makes it a valuable ingredient in topical formulations for wound healing, skin repair, and anti-aging treatments, contributing to enhanced skin health.
Zinc Thymulin, a complex of zinc and thymulin, a thymic peptide, exerts its effects on immune modulation and skin integrity through the activation of T-cells and keratinocytes. Zinc’s ability to enhance the activity of immune cells aids in skin protection and repair (8). Topical formulations containing zinc thymulin may be considered for patients with compromised skin barriers, such as those with eczema or dermatitis. By soothing inflammation and supporting the skin’s natural protective functions, zinc thymulin can help maintain skin health and alleviate discomfort associated with skin conditions.
GHK-Cu (Copper Tripeptide-1) is a copper peptide renowned for its tissue regeneration and anti-inflammatory properties. It has been shown to stimulate the synthesis of extracellular matrix proteins, such as collagen and elastin, contributing to skin rejuvenation and enhanced elasticity (9). Additionally, GHK-Cu exerts potent antioxidant effects, protecting skin cells from oxidative stress. This makes GHK-Cu a valuable ingredient in topical formulations designed for skin rejuvenation and wound healing, as it can promote tissue regeneration and reduce inflammation, thereby supporting overall skin health and appearance.
In the quest for healthy aging, medical practitioners have unveiled the potential of key nutrients such as L-Baiba, ac-11 cat’s claw, 2-HOBA, bergamot, and spermidine, as well as topical ingredients like PTD-DBM, copper tripeptide-1, zinc thymulin, GHK-Cu, Argireline, and Leuphasyl. Understanding the scientific basis of these compounds allows doctors to craft personalized treatment plans for aging patients, fostering overall well-being and vitality. By harnessing the power of these elements, medical practitioners can embark on a journey towards supporting their patients in aging gracefully and preserving their quality of life.
References:
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- Sheng Y, Li L, Holmgren K, Pero RW. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001 Jul;8(4):275-82. doi: 10.1078/0944-7113-00045. PMID: 11515717.
- Mammone T, Akesson C, Gan D, Giampapa V, Pero RW. A water soluble extract from Uncaria tomentosa (Cat’s Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin. Phytother Res. 2006 Mar;20(3):178-83. doi: 10.1002/ptr.1827. PMID: 16521105.
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- Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Spermidine in health and disease. Science. 2018 Jan 26;359(6374):eaan2788. doi: 10.1126/science.aan2788. PMID: 29371440.
- Ryu YC, Lee DH, Shim J, Park J, Kim YR, Choi S, Bak SS, Sung YK, Lee SH, Choi KY. KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neogenesis. Br J Pharmacol. 2021 Jun;178(12):2533-2546. doi: 10.1111/bph.15438. Epub 2021 May 5. PMID: 33751552; PMCID: PMC8251890.
- ER, Vickers. (2017). An Analysis of the Safety and Efficacy of Topical Zinc-Thymulin to treat Androgenetic Alopecia. Hair Therapy & Transplantation. 07. 10.4172/2167-0951.1000147.
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