stay updated with our newsletter

Close this search box.

Specific Ingredients Address the Triad of Cardiovascular Concerns

TruGen3_label logo-1 copy

Cholesterol receives the lion’s share of attention regarding heart health, but in reality, cholesterol is part of a triad of factors that need to be addressed to support the cardiovascular system. Triglycerides and C-reactive protein (CRP) are equally important in heart health. In this article, I’ll discuss the importance of controlling all three of these factors and address the novel ingredients to look for in Heart Support Products to effectively support heart health.


A Healthy Inflammatory Response Drives Heart Health

It is now well known that inflammation plays a critical role in cardiovascular disease.1 Levels of CRP, a systemic inflammatory marker, often are elevated in heart patients. CRP triggers monocyte cytokine expression, expression of adhesion molecules, and platelet aggregation, all of which are connected to cardiovascular disease.2 A number of studies indicate CRP is an independent risk factor for cardiovascular disease, comparable to total and high-density lipoprotein cholesterol or blood pressure.3-5


The Importance of Triglycerides

Elevated triglycerides are implicated in arteriosclerosis, which increases the risk of stroke and heart disease. High triglycerides often accompany obesity and metabolic syndrome, two conditions associated with increased cardiovascular risk. High triglycerides were linked to an increase in all-cause mortality in one recent study.5 High triglycerides are thought to explain why many patients on low-density lipoprotein-lowering therapy are still at risk of atherosclerotic cardiovascular disease.6


Supporting High Cholesterol in the Normal Range

Many doctors find that supporting healthy cholesterol levels in the normal range is still a foundational approach to heart health. In a study published in the journal Circulation, researchers reported that levels of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (HDL-C) that were 160 mg/dL or higher were independently linked to a 50% to 80% increased relative risk of cardiovascular disease mortality, independent of other risk factors.7



From TruGen3, the Sponsor of this article: 

A Cutting-Edge Approach to Supporting Heart Health

Together with exercise and leading a healthy lifestyle, Here are some ingredients to support Cardiovascular health.


Cholesstrinol™ HPe Ultimate Red Yeast Rice

Eastern medicine has used red yeast rice for centuries to support healthy lipid levels. The organic, non-GMO, US-produced red yeast rice in Cholesstrinol™ HPe undergoes rigorous testing to detect the contaminant citrinin and therapeutic levels of monacolin k, the component of red yeast rice known to suppress the production of cholesterols. Other competing red yeast rice products don’t test their formulas for citrinin, a contaminant that may lead to kidney damage. This ensures the utmost safety and effectiveness of TG3 Heart Support.


Highly Bioavailable Coenzyme Q10

CoQ10 is critical for mitochondrial health, energy production, and healthy heart function. Yet, the CoQ10 found in commercial supplements is often poorly absorbed in the intestines. Clinical trials have shown that CoQ10 bioavailability can be enhanced by its delivery system.9 A particularly effective delivery system is known as VESIsorb®, a self-assembling colloidal droplet delivery system, which mimics the physiological absorption pathway of nutritional lipids.

CoQ10 formulated using the patented VESIsorb® delivery system yields superior absorption and bioavailability. In a published human pharmacokinetic study, researchers compared VESIsorb® CoQ10 with three other CoQ10 formulas.9 VESIsorb® CoQ10 was superior to the other three formulas, producing the highest plasma concentration level after one hour compared to the other types of CoQ10 and the levels continued to increase for up to four hours.


PMF-source® Citrus Flavones

A subclass of citrus bioflavonoids that contain an extra methyl group, polymethoxylated flavones (PMF) are known for their cardiovascular benefits. Citrus-derived PMFs, including tangeretin and nobiletin, are especially powerful at supporting healthy lipid levels, as demonstrated in animal models.10,11


Tocosource® Red Palm Tocotrienols

Fresh virgin red palm oil is a rich source of tocotrienols, isomers of natural vitamin E, as well as other nutrients like CoQ10.12 Red palm oil is known to have cardioprotective properties.12 In a human study, red palm oil decreased levels of tissue plasminogen activator antigen.13 Lower levels of this marker may be associated with better cardiovascular health.14



Maintaining optimal cardiovascular health involves not just supporting healthy cholesterol levels but also promoting balanced triglyceride levels and supporting a healthy inflammatory response. The Ingredients mentioned above contain key cardioprotective nutrients that address all three critical factors of heart health as a natural alternative.


Supporting Heart Health with TG3 Heart Support

Together with exercise and leading a healthy lifestyle, TG3 Heart Support formula is a highly effective way to promote heart health. The ingredients in the formula not only support healthy cholesterol metabolism, they also maintain optimal triglyceride levels and support a healthy inflammatory response with a 57% drop in inflammation.8 Research indicates the key ingredients in TG3 Heart Support significantly promote healthy lipid levels, including a 4% improvement in HDL.

The coenzyme Q10 (CoQ10) in TG3 Heart Support Formula is produced using VESIsorb® technology, for superior bioavailability. TG3 Heart Support also contains organic red yeast rice that’s undergone rigorous safety testing for citrinin, ensuring you can trust the safety of this formula. PMF-source citrus flavones and Tocosource® red palm tocotrienols work synergistically with the other ingredients. TG3 Heart Support is a potent natural solution to optimal cardiovascular function.



  1. Ross R. Atherosclerosis–an inflammatory disease. N Engl J Med. 1999;340(2):115-126.
  2. Ruiz-Ramie JJ, Barber JL, Lloyd-Jones DM, et al. Cardiovascular Health Trajectories and Elevated C-Reactive Protein: The CARDIA Study. J Am Heart Assoc. 2021;10(17):e019725.
  3. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342(12):836-843.
  4. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. Circulation. 1998;97(5):425-428.
  5. Kaptoge S, Di Angelantonio E, Lowe G, et al. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet. 2010;375(9709):132-140.
  6. Farnier M, Zeller M, Masson D, Cottin Y. Triglycerides and risk of atherosclerotic cardiovascular disease: An update. Arch Cardiovasc Dis. 2021;114(2):132-139.
  7. Abdullah SM, Defina LF, Leonard D, et al. Long-Term Association of Low-Density Lipoprotein Cholesterol With Cardiovascular Mortality in Individuals at Low 10-Year Risk of Atherosclerotic Cardiovascular Disease. Circulation. 2018;138(21):2315-2325.
  8. Roza JM, Xian-Liu Z, Guthrie N. Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Altern Ther Health Med. 2007;13(6):44-48.
  9. Liu ZX, Artmann C. Relative bioavailability comparison of different coenzyme Q10 formulations with a novel delivery system. Altern Ther Health Med. 2009;15(2):42-46.
  10. Kurowska EM, Manthey JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem. 2004;52(10):2879-2886.
  11. Li RW, Theriault AG, Au K, et al. Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters. Life Sci. 2006;79(4):365-373.
  12. Loganathan R, Subramaniam KM, Radhakrishnan AK, Choo YM, Teng KT. Health-promoting effects of red palm oil: evidence from animal and human studies. Nutr Rev. 2017;75(2):98-113.
  13. Scholtz SC, Pieters M, Oosthuizen W, Jerling JC, Bosman MJ, Vorster HH. The effect of red palm olein and refined palm olein on lipids and haemostatic factors in hyperfibrinogenaemic subjects. Thromb Res. 2004;113(1):13-25.
  14. Lowe GD, Danesh J, Lewington S, et al. Tissue plasminogen activator antigen and coronary heart disease. Prospective study and meta-analysis. Eur Heart J. 2004;25(3):252-259.


Weekly round-up, access to thought leaders, and articles to help you improve health outcomes and the success of your practice.