This paper, published from our partners at Integrative Medicine, A Clinician’s Journal presents an evidence-based strategy for improving clinical outcomes with a phased approach to COVID-19, written by Joe Pizzorno, ND, IMCJ editor-in-chief and co-authors, Sam Yanuck, DC and, Helen Messier, MD, PhD, Kara Fitzgerald, ND. Corresponding author: firstname.lastname@example.org.
ABSTRACT/ Recommendations are based on the phases of the disease, because optimal interventions for one phase may not be appropriate for a different phase. The four phases addressed are: Prevention, Infection, Inflammation and Recovery.
Underlying this phased approach is recognition of emerging evidence for two different components of pathophysiology, early infection and late stage severe complications. These two aspects of the disease suggest two different patterns of clinical emphasis that seem on the surface to be not entirely concordant.
- They describe the application of therapeutic strategies and appropriate tactics that address four main stages of disease progression for COVID-19.
- Emerging evidence in COVID-19 suggests that the SARS-CoV-2 virus may both evade the innate immune response and kill macrophages.
- Delayed innate immune response and a depleted population of macrophages can theoretically result in a blunted antigen presentation, delaying and diminishing activation of the adaptive immune response.
- Thus, one clinical strategy involves supporting patient innate and adaptive immune responses early in the time course of illness, with the goal of improving the timeliness, readiness, and robustness of both the innate and adaptive immune responses.
At the other end of the disease pathology spectrum, risk of fatality in COVID-19 is driven by excessive and persistent upregulation of inflammatory mechanisms associated with cytokine storm. Thus, the second clinical strategy is to prevent or mitigate excessive inflammatory response to prevent the cytokine storm associated with high mortality risk.
Clinical support for immune system pathogen clearance mechanisms involves obligate activation of immune response components that are inherently inflammatory. This puts the goals of the first clinical strategy (immune activation) potentially at odds with the goals of these second strategy (mitigation of pro-inflammatory effects). This creates a need for discernment about the time course of the illness and with that, understanding of which components of an overall strategy to apply at each phase of the time course of the illness.
We review evidence from early observational studies and the existing literature on both outcomes and mechanisms of disease, to inform a phased approach to support the patient at risk for infection, with infection, with escalating inflammation during infection, and at risk of negative sequelae as they move into recovery.
In this article you will learn about a immunological and physiological phased approach to COVID-19:
- Immunological Framework
- Clinical Strategy for Patient Support in COVID-19
- Four Phases in the Time Course of COVID-19
- Five Targets of Support
- Tactics to Support the Clinical Strategy Assessment of Risk Factors
- Tactics for the Five Targets of Support:
- Foundational Support
- Natural Killer (NK) cell support
- Th1 cell support
- Anti-Inflammatory Support
- Anti-Oxidant Support
- Drug – Nutrient Interactions