A Rationale for an Approach to Preventing and Treating Bisphosphonate-related Osteonecrosis of the Jaw With Vitamin K2 Menaquinone-4

 John Neustadt, ND; Steve Pieczenik, MD, PhD 


In this article, the authors describe the Neustadt-Pieczenik Collagen Damage and Restoration Hypothesis, which proposes that medical professionals may prevent and treat osteoporosis and bisphosphonate-related osteonecrosis of the jaw successfully by protecting bone collagen from damage and by stimulating production of new bone collagen. They posit that collagen damage represents the keystone for understanding these diseases. The article discusses studies confirming that collagen production is critical to bone health, fracture healing, and fracture prevention and that MK4, a specific form of vitamin K2, is important for its ability to stimulate collagen production. 

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