“When their stress increases, their symptoms get worse—all of them. Every single symptom.” — Dr. Gaetano Morello
In this episode of the OneMedicine Podcast, Rob Lutz speaks with Dr. Gaetano Morello about practical, evidence-informed approaches to depression, stress, and anxiety in clinical practice. Dr. Morello shares how chronic stress can worsen complex conditions by driving gut permeability, neuroinflammation, and mitochondrial dysfunction, and explains why treating the underlying physiology matters.
The conversation covers the differences between stress and anxiety, the role of the endocannabinoid system, and how botanicals and nutrients like echinacea-derived compounds, saffron, curcumin, GABA, omega-3s, magnesium, and acetyl-L-carnitine may fit into a practitioner’s toolkit.
Dr. Morello also highlights lifestyle foundations, including protein intake, movement, sleep, mindfulness, grounding, and diet, for supporting resilience and long-term health. A practical, wide-ranging discussion for clinicians looking for natural strategies to help patients manage stress-related symptoms and improve overall wellness.
Key Moments
00:00 – Intro
21:00 – Stress causes leaky gut and systemic inflammation
26:00 – Endocannabinoid system role in pain and gut permeability
41:23 – Simple daily habits to support mitochondrial function
Click to Listen
Related Content and Links
Beyond Immunity: How Echinacea EP107 Targets Stress and Anxiety
Stress & Anxiety Resource Center
Speaker Bio
Dr. Gaetano A. Morello, BSc, ND, is a board-certified naturopathic physician with over 30 years of clinical experience. He practices at the Wellness Health Centre in West Vancouver and serves as a clinician in the Complex Chronic Disease Program at BC Women’s Hospital — the first naturopathic doctor to hold such a hospital position in North America. A recognized expert in integrative and functional medicine, Dr. Morello is the author of Whole Body Cleansing and Cleanse: The Ultimate Inside Out Approach, a contributing author to A Textbook of Natural Medicine, and a frequent speaker and consultant in the nutraceutical industry. He specializes in complex chronic conditions and evidence-based natural approaches to stress, anxiety, mood, and overall wellness.
Podcast sponsored by: EuroMedica
