Charles B. Simone II, MD; Nicole L. Simone, MD; Victoria Simone, RN; Charles B. Simone, MD
Introduction
Two of every 5 Americans will develop cancer, and the incidence of most cancers has increased annually since 1930.1-5 In addition, since 1930, despite the use of radiation therapy, chemotherapy, immunothera- py, and improved surgical and diagnostic tech- niques, there has been limited progress in cancer survival for most adult cancers.1-5 Chemotherapy and radiation therapy, how- ever, continue to have a large role in cancer treatment but pro- duce great morbidity. Two prescription medicines, amifostine and dexrazoxane, both antioxidants, reduce cancer therapy side effects without interfering with antitumor killing.
A single, front-page interview in The New York Times in 1997, which was not based on published scientific work,6 and a single research paper involving mice, along with a press release by its author in 1999,7 led to the erroneous notion that vitamin C inter- feres with chemotherapy and radiation in humans. This notion soon applied to all antioxidants as physicians, patients, the media, the American Cancer Society,8,9 and scores of websites took the same position without reviewing the scientific evidence. Methods have been presented in Part 1. Part 2 reviews data about antioxidant combinations, B vitamins, vitamins D3 and K3, and the glutathione-selenium complex. A summary and discussion are presented.
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