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Clinically Supported Menopausal S-equol Product Available to Practitioners

This year alone 53 million women, between the ages of 40 and 64, are entering perimenopause or menopause. both perimenopause and menopausal symptoms can dramatically affect a woman’s quality of life for up to 7.4 years. In response to the growing need for addressing menopausal symptoms, INNATE Response has launched Equelle, a non-hormonal dietary supplement containing S-equol. The ingredient has been clinically shown to help ease the symptoms commonly experienced during menopause, such as hot flashes and muscle discomfort.* The supplement is now available to integrative healthcare professionals exclusively through Emerson Ecologics®.

Low Dog, Todays PractitionerMenopause is a normal, transitionary period of life that all women will eventually experience,” said Tieraona Low Dog, MD, an integrative medical doctor and expert in integrative medicine, women’s health, herbal medicine and dietary supplements. “I’m delighted that clinicians now have the opportunity to recommend Equelle as a part of a total approach in the management of menopause,” says Dr. Low Dog.

S-equol, an Emerging Solution for Menopausal Symptoms

The active ingredient in Equelle is S-equol, a metabolite of the soy isoflavone daidzein, which can be naturally produced in the intestinal tract. Clinical studies have shown that incorporating the regular use of a S-equol supplement like Equelle can ease menopausal symptoms in as few as four weeks, with optimal results shown after eight to 12 weeks of consistent use.* Since only 20 to 30 percent of women in the U.S. have the ability to naturally produce S-equol in their bodies, those seeking to benefit from S- equol to manage menopausal symptoms may find supplementation essential (see FIGURE 1, FIGURE 2).


FIGURE 2Equelle is the product of the fermentation of whole, non-GMO soy germ using a patented and proprietary process by Otsuka Pharmaceutical Co., Ltd.  The process results in the conversion of diadzein to S-equol. Equelle tablets, created under current Good Manufacturing practices, are clear coated and free of gluten, dairy, magnesium stearate and talc, the company claims. Suggested patient use are two Equelle tablets daily, one tablet taken in the morning and one tablet at night, which provide the standardized dose of 10 mg of S-equol.

Download Practitioner Information Sheet on S-equol

Click Here for Tieraona Low Dog, MD: Why Soy Isoflavones Don’t Work for Many Menopausal Women 

Click here for more information on Equelle, or call Emerson Ecologics Customer Service  800.654.4432. For information on this and other INNATE Response products, contact customer support 800.634.6342 or email [email protected]

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
This content was excerpted from materials provided by INNATE Response.
  1. JAMA Intern Med. 2015;175(4):531-539. doi:10.1001/jamainternmed .2014.8063
  2. JAMA. 2016;315(23):2554-2563. doi:10.1001/jama.2016.8012 Use of Plant-Based Therapies and Menopausal Symptoms A Systematic Review and Meta-analysis Oscar H. Franco, MD, PhD1; Rajiv Chowdhury, MD, PhD2; Jenna Troup, MSc1; et al
  3. The 2015 Gallup Study of Menopause Management Multi-sponsor Surveys, Inc.
  4. Atkinson C, et al. Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to daidzein-metabolizing phenotypes among premenopausal women in the United States. Am J Clin Nutr 2008;87:679-687.
  5. Setchell KD, et al. Method of de ning equol-producer status and its frequency among vegetarians. J Nutr 2006;136:2188-93.
  6. A Natural S-equol Supplement Alleviates Hot Flushes and Other Menopausal Symptoms in Equol Non-Producing Postmenopausal Japanese Women. Aso, et al. J Women’s Health (2012).
  7. A Pilot Study on the Effects of S-equol Compared to Soy Iso avones on Menopausal Hot Flash Frequency and Other Menopausal Symptoms. Jenks, et al. J Women’s Health.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


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