Cannabinoid Receptors: Where They Are and What They Do

 Abstract / The endocannabinoid system consists of the endogenous cannabinoids (endocannabinoids), cannabinoid receptors and the enzymes that synthesise and degrade endocannabinoids. Many of the effects of cannabinoids and endocannabinoids are mediated by two G protein‐coupled receptors (GPCRs), CB1 and CB2, although additional receptors may be involved. CB1 receptors are present in veryRead …

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Two JAMA Studies with Podcast: Legal Cannabis Reduces Opioid Prescribing

Legal Cannabis

Recently the Journal of the American Medical Association (JAMA) published two studies and commentary on the relationship between legal cannabis use and opioid prescribing rates and patterns. We provide an 11-minute podcast from the authors and the study abstract summaries below. One study examines state implementation of medical and adult-useRead …

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Could Cannabidiol Be the Answer to Treatment-resistant Epilepsy & Lennox-Gastaut Syndrome?

The level of frustration and hopelessness is high among one-third of epilepsy cases that are resistant to medication. A just-released study in Lancet, outlines how a pharmaceutical formulation of cannabidiol (20 mg/kg daily), alongside other anti-epilepsy treatments, reduced the number of drop seizures – seizures which involve sudden falls due

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Effectiveness of Medical Cannabis for Parkinson’s Disease

Medical Cannabis for Parkinson's
Current treatments of Parkinson disease (PD) and parkinsonism still provide suboptimal effects, especially regarding the patients’ quality of life. This has led to the search for alternative and often unconventional therapies, such as medical cannabis for Parkinson’s Disease (PD). The use of medical cannabis (MC) is controversial. Support for its

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Case Study: Cannabidiol Oil for Pediatric Anxiety and Insomnia

Post traumatic stress disorder presents itself as anxiety, insomnia, an inability to focus and demonstration of oppositional behaviors. In this case study, physicians used cannabidiol oil for treatment of a ten-year old girl with PTSD, and describe it as a safe treatment for reducing anxiety and improving sleep. The followingRead …

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Are your Patients Asking about Cannabis?

As more states are considering legalizing medicinal and recreational marijuana, physicians are increasingly caught by surprise when patients ask about its safety and efficacy. Physicians cite a lack of knowledge about dosing guidelines and a clear understanding of the active ingredients in a recently published JAMA article, Medical Marijuana Is

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