Can Melatonin Treat Irritable Bowel Syndrome (IBS)?
Melatonin is a sleep hormone that helps regulate the body’s circadian rhythm. Intestinal melatonin levels are 400 times higher than in systemic circulation, playing a major role in gut health. It has anxiolytic, anti-inflammatory, antioxidant, and motility-regulating effects. Human studies have shown that supplementation improves motility, visceral sensitivity, and symptoms seen in IBS, gastroesophageal reflux disease (GERD), and inflammatory bowel disease (IBD). Newer studies continue to support the benefit of melatonin with IBS.