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Bugs and Barrier Function

Intestinal epithelial barrier integrity has a great deal to do with how we feel: both physically and mentally. The concept is a relatively simple one, although the mechanisms are complex. A single layer of epithelial cells functions as a physical barrier between the intestinal lumen, the lamina propria, and theRead

Gut Brain Connection: Talk Along the HPA Axis

The Hypothalamic-Pituitary-Adrenal Axis, or HPA Axis, is a bidirectional neuroendocrine network that modulates our adaptive stress response. The activation loop begins in the hypothalamus with corticotropin-releasing hormone (CRH). Once released, CRH binds to receptors on the anterior pituitary gland resulting in the subsequent release of adrenocorticotropic hormone (ACTH). In turn,Read

Gut Microbes Help with Early Detection of Gestational Diabetes

Gestational diabetes mellitus (GDM), a condition that affects approximately 10% of pregnancies worldwide, occurs when women without diabetes develop glucose intolerance during pregnancy. Typically detected in the second trimester, it can cause adverse outcomes including miscarriage, premature delivery, fetal malformation, and preeclampsia. Now, a new study by Bar-Ilan University inRead

Link Between Gut Bacteria, Estradiol, and Depression Discovered

Omega-3 fatty acids clinical guidelines

A potential new cause of depression in premenopausal women has been uncovered. According to a study in the journal Cell Metabolism, women struggling with depression during their reproductive years have lower levels of estradiol — and the microbiome appears to play a significant role in this connection. Previous research showsRead