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BMP-9: A Promising Therapeutic Target for Bone Destruction in Rheumatoid Arthritis

BMP-9 deficiency exacerbates joint inflammation and promotes bone loss. Researchers tested BMP-9 supplementation in mice to see if there was improvement in any of the pathophysiological features of RA. They injected BMP-9 into the knee joint at weeks 0, 2, 4, and 6 and monitored its effect via CT scan each week after injection. They also monitored BMP-9 expression in the groups that received the injection and found that expression increased significantly.

BMPs and Bone Metabolism

Traditional therapies slow bone loss but don’t rebuild it. This article explains how BMPs play a key role in regenerating bone and cartilage tissue through stem cell activation—transforming how we approach osteoporosis and osteoarthritis.