This episode of the OneMedicine Podcast features an in-depth discussion on the new frontiers of regenerative health and medicine, with a deep dive into BMP (bone morphogenetic protein) complexes. Our guests are Jim Scaffidi, CEO of Regenerative Tissue Science, and Dr. Yan Kim, a researcher and expert in BMPs. TheyRead
From groundbreaking orthopedic surgery to patented oral formulas, learn how BMP-complexes like Cyplexinol® are transforming bone and joint health.
Discover how bone morphogenetic proteins (BMPs) are shifting treatment paradigms—offering regenerative solutions for bone loss and joint degeneration beyond symptom relief.
Traditional therapies slow bone loss but don’t rebuild it. This article explains how BMPs play a key role in regenerating bone and cartilage tissue through stem cell activation—transforming how we approach osteoporosis and osteoarthritis.
BMP-complex from human bone are known as demineralized bone matrix (DBA used in surgery, in which the hydroxyapatite (mineral) component as well as cells (osteoblast and osteoclast are removed.7,13,21,22 Cyplexinol® is the first food-sourced BMP complex from bovine cortical leg bone. Cows are grass-fed, organic, and hormone-free.7,20 This oral complex contains allRead
BMP-9 deficiency exacerbates joint inflammation and promotes bone loss. Researchers tested BMP-9 supplementation in mice to see if there was improvement in any of the pathophysiological features of RA. They injected BMP-9 into the knee joint at weeks 0, 2, 4, and 6 and monitored its effect via CT scan each week after injection. They also monitored BMP-9 expression in the groups that received the injection and found that expression increased significantly.
Key Points: A 50-y-old Caucasian male came into an arthritic care clinic to request a screening for osteoporosis. The patient was in excellent physical health, with no recent illnesses, no medical history of inflammatory conditions or musculoskeletal issues or bone fractures, and at the time was not taking any medications.Read
We compared the impact of a dietary supplement protein complex (Cyplexinol®) and placebo in 18 men and women (aged 43 ± 10 years) with self-reported joint pain. Cyplexinol® (a Bone Morphogenetic Protein [BMP] Complex) is another agent with potential effects. BMPs are growth factors that have been shown to activateRead
A randomized, placebo-controlled trial found Cyplexinol significantly improved joint pain, stiffness, and function in patients with osteoarthritis of the hip and knee. This natural osteoinductive supplement may offer a novel adjunctive approach to OA management.
Osteoarthritis, also known as degenerative joint disease, is one the most common forms of joint disorder in the United States and affects over 20 million people. Current treatments for its management involve the use of analgesics such as acetaminophen and nonsteroidal, anti-inflammatory drugs (NSAIDs). These treatments, however, have shown…
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