BMP-9: A Promising Therapeutic Target for Bone Destruction in Rheumatoid Arthritis
BMP-9 deficiency exacerbates joint inflammation and promotes bone loss. Researchers tested BMP-9 supplementation in mice to see if there was improvement in any of the pathophysiological features of RA. They injected BMP-9 into the knee joint at weeks 0, 2, 4, and 6 and monitored its effect via CT scan each week after injection. They also monitored BMP-9 expression in the groups that received the injection and found that expression increased significantly.
