The Sympathetic Spiral of Doom: Why So Many Patients Stay Stuck
Many patients continue to experience fatigue, anxiety, poor sleep, and low resilience even when conventional testing appears normal. On the One Medicine Podcast, Dr. Scott Scher explores the “sympathetic spiral of doom”—a framework for understanding how mitochondrial dysfunction, oxidative stress, autonomic imbalance, and immune-endocrine signaling may reinforce one another. He explains why energy may need to come first, how treatment can backfire when it is introduced too soon, and how clinicians can better sequence care.