Pink, yellow, or blue? Each of these non-caloric sweeteners may be contributing to the global epidemic of diabetes. The study published in Nature today (Sept. 17, 2014), shows the non-nutritive sweeteners, saccharin, sucralose and aspartame, could actually hasten the development of glucose intolerance and metabolic disease. The mechanism is surprising: these no-calorie sweeteners change the composition and function of gut microbiota. The researchers found the results so compelling they went so far as to call for a reassessment of non-nutritive sweeteners. By Eran Segal, Eran Elinav, published in Nature, Sept. 17, 2014.