The Cascade and Its Limits: Interferon, Homeostatic Capacity, and Treatment Variability in Lupus (Part 2)
Systemic lupus erythematosus does not emerge randomly in patients carrying latent EBV. In this Part 2 of our Systems Homeostasis series, we trace how EBNA2-driven B cell reprogramming, the IFN-I amplification loop, and depleted “circuit breakers” such as IL‑10, Tregs, DNase activity, and antioxidant capacity converge to determine disease expression and treatment response. Clinicians gain a practical framework for reading IFN-I signatures and upstream signal environment data long before full diagnostic criteria are met.
