Peripheral Artery Disease

This interventional study measured the acute effect of dark chocolate on walking distance autonomy (WDA), artery dilatation and NOX2‐mediated oxidative stress in a population affected by moderate‐severe. Previous studies with antioxidant infusion provided evidence that oxidative stress is implicated in impairing WDA, while its inhibition was associated with maximal walking distance (MWD) improvement. In PAD patients dark but not milk chocolate acutely improved walking autonomy with a mechanism possibly related to an oxidative stress‐mediated mechanism involving NOX2 regulation.