This interventional study measured the acute effect of dark chocolate on walking distance autonomy (WDA), artery dilatation and NOX2‐mediated oxidative stress in a population affected by moderate‐severe. Previous studies with antioxidant infusion provided evidence that oxidative stress is implicated in impairing WDA, while its inhibition was associated with maximal walking distance (MWD) improvement. In PAD patients dark but not milk chocolate acutely improved walking autonomy with a mechanism possibly related to an oxidative stress‐mediated mechanism involving NOX2 regulation.
The biggest threat to global health and wellness can be narrowed down to six, preventable non-communicable diseases: respiratory illness from tobacco use, harmful alcohol use, salt intake, high blood pressure and blood sugar, and obesity. According to a May 2014 Lancet study, if nations could reduce target levels for these lifestyle related diseases in the next 25 years, 37 million early deaths would be prevented. But by not reaching these targets, an additional 10.5 million deaths would occur as compared to the 28.3 million who died in 2010. And while experts say this could be possible, critics say apathy from leadership is the biggest obstacle to achieving the desired target.