Christine Krall, ND 
Today’s cardiometabolic care is moving beyond a singular focus on LDL cholesterol toward a more comprehensive therapeutic strategy. Properly formulated and prescribed, niacin merits renewed consideration as an evidence-based nutritional intervention that favorably impacts multiple lipid parameters associated with atherosclerotic CVD.
Daylight and artificial light at night suppress melatonin secretion, which is why we tell our patients to turn off devices before bedtime. Even household lighting at night can contribute to this effect, and it’s important to choose lighting that’s better aligned with natural circadian rhythms. Some studies have shown that typical home lighting induces significant melatonin suppression, up to 50%.
Among PD patients, those with SIBO and/or H. pylori had more unpredictable motor fluctuations. SIBO treatment resulted in significantly improved motor fluctuations without interfering with levodopa efficacy. Since PD is a progressive disease, optimizing gut health will need to be ongoing.
Every so often, a scientific article hits the press, causing patients to question their supplement regimens. A new publication has raised questions about glucosamine, a popular supplement used for arthritis and joint health, and its possible link to Alzheimer’s disease (AD).
Even acknowledging the potential benefits of carnivore and keto diets for some conditions, it’s hard to ignore the extensive meta-analytic evidence linking higher fiber intake with better health outcomes. For most people, increasing fiber intake is a low-risk change with considerable potential upside.
While lifestyle changes are important, compliance can be challenging, and other strategies like targeted supplements can help manage oxidative stress, inflammation, and insulin resistance. Notably, this article includes several meta-analyses of randomized controlled trials (RCTs) examining the effects of various nutrients on MASLD, providing a robust synthesis of the available evidence. Enhanced efficacy is seen when these therapies are paired with a Mediterranean diet and other healthy lifestyle changes.
A quick dive into PubMed yields numerous human studies on resveratrol in the past year alone. These recent studies show benefits for patients with osteoarthritis, cardiometabolic disease, Alzheimer’s disease, COVID-19, polycystic ovarian syndrome (PCOS), and periodontal disease. Its antioxidant and anti-inflammatory actions make resveratrol a good consideration for patients’ baseline health regimens.
Clinicians are eager to treat with PERT, but it’s always important to ask, “Why does this patient have EPI, or why are their FE-1 levels suboptimal (<500 μg/g)?” Some underlying causes can be treated, which means pancreatic function can return to normal, and patients are not reliant on PERT with every meal long-term. For example, celiac patients with EPI who start a gluten-free diet restore the mucosal lining and often normalize pancreatic function and FE-1 levels within months.
A meta-meta-analysis was performed on randomized controlled trials examining exercise interventions for depression and anxiety symptoms in 79,551 participants. All population groups, including children and adults aged 10-90 with clinically diagnosed and subclinical symptoms, were included. Populations with chronic physiological conditions were excluded to better isolate the effects of exercise, allowing researchers to determine whether exercise alone improves mental health independently.
MCP has demonstrated significant anticancer activity in vitro, in animal studies, and in clinical studies. Beyond its anticancer properties, MCP is shown to improve metal detoxification, immune function, cardiovascular function, and reduce fibrosis to the kidney, liver, and adipose tissue. Together, this body of evidence positions MCP as a promising, multi-targeted intervention with applications in oncology and chronic disease management.
