Christine Krall, ND 
A quick dive into PubMed yields numerous human studies on resveratrol in the past year alone. These recent studies show benefits for patients with osteoarthritis, cardiometabolic disease, Alzheimer’s disease, COVID-19, polycystic ovarian syndrome (PCOS), and periodontal disease. Its antioxidant and anti-inflammatory actions make resveratrol a good consideration for patients’ baseline health regimens.
Clinicians are eager to treat with PERT, but it’s always important to ask, “Why does this patient have EPI, or why are their FE-1 levels suboptimal (<500 μg/g)?” Some underlying causes can be treated, which means pancreatic function can return to normal, and patients are not reliant on PERT with every meal long-term. For example, celiac patients with EPI who start a gluten-free diet restore the mucosal lining and often normalize pancreatic function and FE-1 levels within months.
A meta-meta-analysis was performed on randomized controlled trials examining exercise interventions for depression and anxiety symptoms in 79,551 participants. All population groups, including children and adults aged 10-90 with clinically diagnosed and subclinical symptoms, were included. Populations with chronic physiological conditions were excluded to better isolate the effects of exercise, allowing researchers to determine whether exercise alone improves mental health independently.
MCP has demonstrated significant anticancer activity in vitro, in animal studies, and in clinical studies. Beyond its anticancer properties, MCP is shown to improve metal detoxification, immune function, cardiovascular function, and reduce fibrosis to the kidney, liver, and adipose tissue. Together, this body of evidence positions MCP as a promising, multi-targeted intervention with applications in oncology and chronic disease management.
Studies have shown that garlic addresses the overlapping pathogenic mechanisms of MetS and PCOS. Bioactive compounds in garlic, including allicin, can impact oxidative stress, apoptosis, inflammation, and vascular remodeling. A 2023 systematic review and meta-analysis of 19 RCTs concluded that garlic favorably impacts MetS variables, including serum lipids, blood pressure, and body composition.
Patients with confirmed or suspected SIBO commonly show dysbiosis on stool testing, including altered beneficial short-chain fatty acids (SCFAs) like butyrate, which support gut integrity and reduce inflammation. This creates a clinical dilemma: therapies that support the microbiome and SCFA balance, such as fiber, prebiotics, and probiotics, may worsen SIBO symptoms, while antimicrobials and LFDs can further drive dysbiosis.
Melatonin is a sleep hormone that helps regulate the body’s circadian rhythm. Intestinal melatonin levels are 400 times higher than in systemic circulation, playing a major role in gut health. It has anxiolytic, anti-inflammatory, antioxidant, and motility-regulating effects. Human studies have shown that supplementation improves motility, visceral sensitivity, and symptoms seen in IBS, gastroesophageal reflux disease (GERD), and inflammatory bowel disease (IBD). Newer studies continue to support the benefit of melatonin with IBS.
Precision medicine demonstrated a substantially larger effect on overall cognitive function than previously reported trials—approximately seven times greater than lecanemab and four times greater than donanemab—without the negative side effects.
There is not one strictly antiparasitic herb; rather, most herbs treat multiple microorganisms, including bacteria, yeast, and parasites, and have other beneficial biological properties. This is the beauty of herbs, compared to medications, which often have targeted actions. This also may be why herbal antiparasitic blends are likely successful—they are treating underlying general dysbiosis and pathogens and have other healing properties that support gut and overall health.
It’s well known that fatty acids mediate inflammation. Omega-3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) found in cold water fish and fish oil supplements, produce metabolites in the body called specialized pro-resolving mediators (SPMs). SPMs include resolvins, maresins, lipoxins, and protectins, and help to resolve inflammation andRead
